Ray Peat: Serotonin the Hormone of Depression and Defeat

In the realm of neuroscience and psychology, serotonin has long been labeled as the “happy hormone,” a perception that has shaped the development and prescription of numerous antidepressants. However, Ray Peat, a respected biologist and physiologist, presents a dramatically different view of serotonin, positioning it as a mediator of depression and defeat rather than a promoter of happiness.

The Misunderstood Role of Serotonin

Peat’s extensive research suggests that the increase of inhibitory serotonin during stress and depression is biologically akin to the role of serotonin in hibernation, a state of withdrawal and harm avoidance. He indicates that certain diets, specifically those high in polyunsaturated fat, can enhance the brain’s uptake of tryptophan, leading to increased serotonin levels. This elevation in serotonin, Peat argues, is associated with a decrease in body temperature and a dampening of biochemical reactions, contributing to a depressive state​​​​.

Serotonin’s Impact on Inflammation and Energy Production

Contrary to popular belief, Peat points out that serotonin actually increases inflammation and activates the stress system, while simultaneously reducing the efficiency of energy production. This perspective challenges the widely held view of serotonin as a mood elevator and highlights the pharmaceutical industry’s role in perpetuating this myth​​.

SSRIs and the Serotonin Myth

Peat critiques the use of SSRIs (Selective Serotonin Reuptake Inhibitors), a common class of antidepressants. He notes that these drugs’ supposed therapeutic value is often overemphasized, overshadowing their associations with obesity, sexual dysfunction, hair loss, and osteoporosis. Moreover, he argues that the increase in serotonin and tryptophan levels is actually linked to depression, suicidality, anxiety, aggression, and violence​​.

Peat’s research further reveals that serotonin interferes with sugar metabolism, which can lead to diabetes and obesity. He also discusses how darkness increases the appetite for alcohol, a phenomenon that can be mitigated by anti-serotonin drugs, suggesting that alcohol consumption might be a self-medication method for serotonin-related depression​​.

Long-term Effects and Potential Solutions

Peat highlights the potential of anti-serotonin measures in preventing, alleviating, and sometimes curing problems caused by stress and serotonin dominance, such as cancer, dementia, arthritis, and other debilitating conditions. He expresses concern about the pharmaceutical industry’s potential interference in the use of safe, inexpensive substances that effectively address these issues​​.

A New Perspective on Depression and Serotonin

Peat’s findings challenge the conventional understanding of serotonin’s role in depression. He emphasizes the need for a reevaluation of the current approach to treating depression, advocating for a shift away from serotonin-centric therapies and towards more holistic and effective treatments​​​​.

Conclusion

Ray Peat’s work presents a compelling argument for rethinking the role of serotonin in depression. By highlighting the hormone’s association with stress, inflammation, and reduced energy production, Peat urges the medical community to reconsider the widespread use of SSRIs and to explore alternative approaches to treating depression and related disorders. His insights into serotonin’s broader impact on health and well-being are a crucial contribution to the ongoing debate about mental health treatment and the role of neurotransmitters in our psychological states.