Ray Peat: the Importance of Co2

Carbon dioxide (CO2) plays a crucial role in the human body, a fact often overlooked by many in the scientific community. Ray Peat, a respected biologist and nutritionist, has extensively studied the multifaceted roles of CO2, highlighting its importance beyond mere waste product of respiration. This article, drawing upon Peat’s research, aims to elucidate the often underestimated significance of CO2 in various biological processes.

Intracellular Regulation and Disease Prevention

One of Peat’s key insights is the role of CO2 in regulating intracellular pH and its protective effects against cellular excitability. By increasing intracellular CO2 levels, lactic acid formation is inhibited, thereby restoring the oxidation of glucose. This process leads to a lowering of intracellular pH, which has broad protective anti-excitatory effects. This regulation plays a role in disease prevention, as evidenced by studies showing a decrease in cancer mortality at higher altitudes, where atmospheric CO2 concentrations are greater​​​​.

Influence on Calcium and Sodium Regulation

CO2 is also intricately involved in the regulation of vital ions such as calcium and sodium. Excessive intracellular calcium can be detrimental, leading to overactivation of enzymes, muscle and nerve cell dysfunction, and eventually cell death. CO2 helps in removing excess calcium from cells, thereby preventing these harmful effects. Additionally, the presence of CO2 regulates sodium-potassium ATPase, an enzyme essential for maintaining cellular energy balance and preventing toxic effects of intracellular calcium​​.

Respiration and Energy Production

A notable aspect of Peat’s research is the exploration of CO2’s role in respiration and energy production. CO2 binds to hemoglobin, regulating its affinity for oxygen. This binding suggests that CO2 might also regulate the functions of other intracellular proteins, influencing cellular respiration and energy dynamics​​.

Consciousness and Brain Metabolism

Peat postulates that CO2 is essential not just for basic cellular functions but also for higher-order processes like consciousness. The brain, having a high rate of oxidative metabolism, produces a large proportion of an organism’s CO2. This CO2 production is closely linked to the brain’s metabolic activities, including oxygen consumption and lactic acid production. Peat suggests that the presence of CO2, along with ATP, might be required to maintain the sensitive state of consciousness by stabilizing cytoplasmic proteins​​.

Carbon Dioxide in Organisms and Ecosystems

Beyond human physiology, CO2’s role extends to various organisms and ecosystems. For instance, it is critical in the salt glands of some animals, helping in the excretion of salt and regulation of water and solutes. This function is particularly evident in young salmon adapting to oceanic saltwater, where CO2 production is linked to thyroid hormone activity​​. Moreover, in beehives and mole rat colonies, CO2 levels are carefully regulated, impacting reproductive processes and possibly contributing to cancer resistance​​.

Misconceptions and Underappreciation

Despite these diverse roles, CO2 is often misunderstood and undervalued in biological research. It is commonly regarded as a mere byproduct of respiration or even as a toxin in excess. However, Peat emphasizes that increasing CO2 does not necessarily lead to harmful acidosis, and in many cases, CO2-induced acidosis is less damaging than lactic acidosis. This reevaluation of CO2’s role could lead to new insights and treatments in various medical fields​​.

Conclusion

Ray Peat’s research into CO2 challenges conventional medical and biological wisdom, highlighting the compound’s essential role in a myriad of physiological processes. From cellular function to brain activity, and even in broader ecological contexts, CO2 proves to be much more than a simple waste product. Its critical role in health and disease prevention underscores the need for a deeper understanding and appreciation of this ubiquitous molecule in biological sciences.